A group of researchers from the Badalona Utilized Analysis Group in Oncology (B·ARGO) and the Urologic Tumors Unit of the Institut Català d’Oncologia (ICO) and the Germans Trias i Pujol Analysis Institute (IGTP) have discovered a brand new therapeutic technique for sufferers with a selected subtype of metastatic prostate most cancers resistant to straightforward chemotherapy therapy with docetaxel.
On this research, revealed within the journal Frontiers in Pharmacologythey suggest a brand new therapy based mostly on a mixture of kinase inhibitors in sufferers who inevitably cease responding to docetaxel.
The group discovered that resistance to this drug is related to the hyperactivation of the mobile pathways PI3K/AKT and MEK/ERK and have explored the potential for inhibiting these pathways as a brand new therapeutic technique in sufferers who keep the perform of PTEN, a destructive regulatory protein of the PI3K/AKT pathway.
The outcomes of the research have been passable and, because of this, the group desires to conduct a medical trial to evaluate the security and efficacy of this mix in sufferers with prostate most cancers immune to docetaxel.
Vicenç Ruiz de Porras and Adrià Bernat-Peguera, ICO-IGTP researchers and co-first authors of the research, state that the outcomes of this research “open the door to a brand new therapeutic technique for these sufferers with PTEN wild-type tumors, who’ve progressed to docetaxel and in whom, in contrast to PTEN null patientsthe efficacy of AKT inhibitors in monotherapy has not been demonstrated.”
Vicenç Ruiz de Porras et al, Twin inhibition of MEK and PI3Kβ/δ–a possible therapeutic technique in PTEN-wild-type docetaxel-resistant metastatic prostate most cancers, Frontiers in Pharmacology (2024). DOI: 10.3389/fphar.2024.1331648
Germans Trias i Pujol Analysis Institute
New therapeutic technique for metastatic prostate most cancers sufferers resistant to straightforward therapy (2024, February 2)
retrieved 4 February 2024
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