A brand new analysis paper titled “Alcohol consumption and epigenetic age acceleration across human adulthood” has been printed in Getting older.
The alcohol-associated biological aging stays to be studied throughout maturity. Of their new research, the researchers performed linear regression analyses to analyze the associations between alcohol consumption and two DNA methylation-based organic age acceleration metrics in 3,823 Framingham Coronary heart Research members (24–92 years and 53.8% ladies), adjusting for covariates.
The researchers state, “We additionally investigated whether or not the 2 epigenetic getting old metrics mediated the affiliation of alcohol consumption with hypertension.”
They discovered that increased long-term common alcohol consumption was considerably related to organic age acceleration assessed by GrimAge acceleration (GAA) and PhenoAge acceleration (PAA) in middle-aged (45–64 years, n = 1,866) and older (65–92 years, n = 1,267) members whereas not in younger members (24–44 years, n = 690).
For instance, one further normal drink of alcohol (~14 grams of ethanol per day) was related to a 0.71 ± 0.15-year (p = 2.1e-6) and 0.60 ± 0.18-year (p = 7.5e-4) enhance in PAA in middle-aged and older members, respectively, however the affiliation was not important in younger members (p = 0.23).
One further normal serving of liquor (~14 grams of ethanol) was related to a larger enhance in GAA (0.82-year, p = 4.8e-4) and PAA (1.45-year, p = 7.4e-5) than beer (GAA: 0.45-year, p = 5.2e-4; PAA: 0.48-year, p = 0.02) and wine (GAA: 0.51-year, p = 0.02; PAA: 0.91-year, p = 0.008) in middle-aged participant group.
“We noticed that as much as 28% of the affiliation between alcohol consumption and hypertension was mediated by GAA or PAA within the pooled pattern. Our findings recommend that alcohol consumption is related to larger organic getting old quantified by epigenetic getting old metrics, which can mediate the affiliation of alcohol consumption with quantitative traits, reminiscent of hypertension,” the researchers conclude.
Mengyao Wang et al, Alcohol consumption and epigenetic age acceleration throughout human maturity, Getting older (2023). DOI: 10.18632/aging.205153
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Analyzing alcohol consumption and epigenetic age acceleration throughout human maturity (2023, November 14)
retrieved 14 November 2023
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