Cannabidiol (CBD) is marketed by some suppliers as a painkiller, e.g., for osteoarthritis of the knee. Animal experiments have proven that the substance, which is extracted from the hemp plant, has an anti-inflammatory and pain-relieving impact in arthritis. As ache researchers at MedUni Vienna have been now capable of present for the primary time in people, CBD shouldn’t be efficient as ache medicine, even in excessive doses.
The outcomes of the scientific research involving sufferers from the Division of Anesthesia, Intensive Care Medication and Ache Medication at MedUni Vienna and College Hospital Vienna have simply been published in The Lancet Regional Well being—Europe.
The research included 86 women and men with a mean age of about 63 years who suffered from severe pain due degeneration of the knee joint (osteoarthritis). Whereas half of the sufferers acquired high-dose cannabidiol (CBD) by the mouth, the opposite group was given a placebo that was not recognizable as such, i.e., a drug with out an active ingredient.
The strictly managed research interval of eight weeks confirmed that CBD didn’t have a stronger pain-relieving impact than the placebo. “Because of this CBD shouldn’t be an alternate for ache remedy for osteoarthritis of the knee, so the seek for more practical choices should proceed,” says Sibylle Pramhas (Division of Particular Anesthesia and Ache Medication, Division of Anesthesia, Normal Intensive Care Medication and Ache Remedy at MedUni Vienna and College Hospital Vienna), first creator of the research.
At present, knee ache related to osteoarthritis is handled with analgesics reminiscent of diclofenac, ibuprofen and/or tramadol. Uncomfortable side effects, but in addition contraindications because of the largely aged sufferers affected, are proving to be main challenges. The analgesic impact of CBD proven in animal research may have offered a brand new therapy choice, however clinical studies with sufficiently excessive CBD doses have to this point been lacking.
“Our research is the primary to supply strong info on the dearth of analgesic potential of CBD in a typical power ache situation, because of the comparatively excessive oral dosage and the lengthy commentary interval,” says Pramhas. Pramhas and the MedUni Vienna analysis crew level out that if this potential can’t be demonstrated even with high-dose oral medicine, then skepticism is much more applicable with CBD-containing painkillers for utility to the pores and skin.
Cannabidiol is a pure substance extracted from the hemp plant and is freely obtainable on the market within the EU. CBD has no demonstrable intoxicating impact and isn’t topic to the Narcotics Act. Liver toxicity is a identified aspect impact. In drugs, the lively ingredient has at the moment solely been sufficiently researched and permitted beneath pharmaceutical legislation for the drug remedy of sure sorts of childhood epilepsy (Dravet syndrome, Lennox-Gastaut syndrome).
Future analysis must present whether or not different medical purposes might be confirmed. “Based on our research, ache reminiscent of that brought on by knee osteoarthritis shouldn’t be certainly one of them,” concludes Pramhas.
Sibylle Pramhas et al, Oral cannabidiol (CBD) as add-on to paracetamol for painful power osteoarthritis of the knee: a randomized, double-blind, placebo-controlled scientific trial, The Lancet Regional Well being—Europe (2023). DOI: 10.1016/j.lanepe.2023.100777
Medical University of Vienna
CBD as a painkiller: Efficacy not clinically confirmed (2023, November 14)
retrieved 14 November 2023
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