What Is Somatic Genomic Testing and How Is It Used in Cancer Treatment?

The American Society of Medical Oncology (ASCO) printed a brand new provisional scientific opinion, “Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer,” on February 17, 2022. Provisional scientific opinions are suggestions for care based mostly on the most recent data in most cancers care. Somatic genomic testing seems for modifications within the genes of most cancers cells. The outcomes are used to plan therapy, together with using targeted therapy and immunotherapy.

On this podcast, Funda Meric-Bernstam, MD, and Mark Robson, MD, talk about what individuals with metastatic or superior most cancers ought to find out about somatic genomic testing and the suggestions from the provisional scientific opinion. Dr. Meric-Bernstam and Dr. Robson had been co-chairs of the ASCO skilled panel that developed these suggestions.

• What’s a provisional scientific opinion, and why are they necessary? [1:58]

• What’s somatic genomic testing, and the way is it utilized in most cancers therapy? [2:54]

• How is somatic testing completely different from germline testing? [4:29]

• What’s next-generation sequencing for most cancers? [5:51]

• What ought to individuals with most cancers and their family members find out about suggestions on this provisional scientific opinion on who ought to have somatic genomic testing? [6:32]

• Is genetic testing achieved via a biopsy pattern? Are there different methods genetic testing will be achieved? [9:55]

• What are the rising ways in which genetic testing could also be used to assist individuals with most cancers? [11:09]

Dr. Meric-Bernstam is the chair of the Division of Investigational Most cancers Therapeutics—the Section I Program on the College of Texas MD Anderson Most cancers Heart in Houston, Texas. Dr. Meric-Bernstam can be the medical director of the Institute for Personalised Most cancers Remedy (IPCT) and the Nellie B. Connally Chair in Breast Most cancers at her establishment. Dr. Robson is the chief of Breast Medication Service at Memorial Sloan Kettering Most cancers Heart in New York, New York.

View Dr. Meric-Bernstam’s disclosures. View Dr. Robson’s disclosures.

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