Pediatric ICU admissions for SARS-CoV-2 decreased across waves

Throughout successive waves of extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), there was a lower in intensive care unit (ICU) admissions throughout ages, whereas ventilatory and oxygen assist diversified by age, based on a examine revealed on-line Aug. 21 in JAMA Pediatrics.

Yanshan Zhu, from the College of Queensland in Australia, and colleagues examined whether or not the dominant circulating SARS-CoV-2 VOCs have been related to variations in COVID-19 severity in hospitalized youngsters (youthful than 18 years) utilizing information obtained from 9 international locations throughout three time frames. Timeframes (T) 1, 2, and three have been outlined to characterize durations of dominance by the ancestral virus, pre-omicron VOCs, and omicron, respectively.

Information have been included for 31,785 hospitalized youngsters and adolescents. The researchers discovered that for kids youthful than 5 years, there was a discount in ICU admission throughout successive SARS-CoV-2 waves (T3 versus T1: danger ratios [RRs], 0.56 and 0.61 for <6 months and 6 months to <5 years, respectively); no discount was seen in ventilatory assist or oxygen remedy. In children aged 5 years to <18 years, there have been decreases in ICU admission, ventilatory assist, and oxygen remedy throughout SARS-CoV-2 waves (T3 versus T1: RRs, 0.39, 0.37, and 0.47, respectively).

“These findings spotlight the significance of contemplating completely different pediatric age teams when assessing illness severity in SARS-CoV-2,” the authors write.

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