GLS2 shapes ferroptosis in hepatocellular carcinoma

A brand new editorial paper titled “GLS2 shapes ferroptosis in hepatocellular carcinoma” has been revealed in Oncotarget.

Of their new editorial, researchers Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, and Carol Prives from Columbia College talk about ferroptosis regulation of GLS2 as a possible therapeutic technique towards liver ailments.

“Greater than a decade has handed since our group in addition to Hu et al., recognized glutaminase (GLS2) as a p53 goal gene that promotes the tricarboxylic acid cycle (TCA) by way of α-ketoglutarate (αKG) and lowers oxidative stress by way of rising glutathione (GSH),” the researchers write.

Two years after this Dixon et al., described a type of cell dying they named ferroptosis which is brought on by iron-mediated lipid peroxidation. Then, three years later, Gao et al., reported that GLS2 however not GLS1 is an inducer of ferroptosis in human most cancers cells. Ferroptosis had first been proven to be regulated by p53 by way of repression of SLC7A11. The circle was closed by a examine from the Murphy group who reported {that a} cancer-related nonsynonymous mutation in p53 (P47S) is correlated with failure to both activate GLS2 expression or produce ferroptosis.

“Our current examine (Suzuki et al.) has validated the power of GLS2 to advertise ferroptosis in murine fashions,” the researchers conclude.

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