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After the Ladies’s Well being Initiative (WHI) in 2002, many ladies have resisted taking hormone remedy (HT), particularly after age 65 years, due to fears of elevated dangers for varied cancers and coronary heart illness. A brand new research reveals that these fears could also be unfounded, relying on the kind, route, and dose of HT. Outcomes of the research are published on-line in Menopause in a paper titled “Use of menopausal hormone remedy past age 65 years and its results on girls’s well being outcomes by sorts, routes, and doses.”
Regardless of the conflicting outcomes of a follow-up WHI research in 2004 and dozens of different research since that point, a share of well being care professionals and their middle-aged feminine sufferers proceed to consider that HT, particularly when taken previous the age of 65 years, can improve the incidence of invasive breast cancer, stroke, and coronary heart disease.
Such fears have prevented many menopausal girls from getting reduction from such signs as scorching flashes as a result of HT is at this time acknowledged as being the best remedy choice for managing an array of bothersome signs related to the menopause transition.
A brand new large-scale research primarily based on the data of 10 million senior Medicare girls from 2007 to 2020, nevertheless, means that the implications of HT use past age 65 years fluctuate by sort, route, and dose. These findings are in keeping with the 2022 HT Place Assertion of The Menopause Society that states there isn’t a basic rule for stopping HT in a lady primarily based on age alone.
The assertion goes on to say that, for wholesome girls with persistent scorching flashes, persevering with HT past age 65 years is an affordable choice with applicable counseling and common evaluation of dangers and advantages. Furthermore, the mitigation of dangers via the selection of low-dose and non-oral routes of administration turns into more and more vital as girls age.
A problem, up to now, has been that data on the consequences of various HT formulations, doses, and routes of administration is missing. That is why the researchers on this newest research particularly sought to evaluate using HT past the age of 65 years and its well being implications by the kind of estrogen and progestogen, route of administration, and dose.
Based mostly on the outcomes of the research, the researchers concluded that, in contrast with by no means use or discontinuation of HT earlier than the age of 65 years, using estrogen monotherapy past age 65 years was related to important threat reductions in mortality, breast most cancers, lung cancer, colorectal most cancers, congestive coronary heart failure, venous thromboembolism, atrial fibrillation, acute myocardial infarction, and dementia.
The usage of a mixture estrogen and progestogen remedy was discovered to extend the danger of breast most cancers, however such threat may be mitigated utilizing low doses of transdermal or vaginal progestin. As well as, progestin utilization resulted in important threat reductions in endometrial most cancers, ovarian most cancers, ischemic coronary heart illness, congestive heart failure, and venous thromboembolism.
“This huge observational research of ladies in Medicare gives reassurance relating to the security of longer-term hormone therapy use and even potential advantages, notably in women utilizing estrogen alone. It additionally gives vital insights into variations amongst totally different hormone remedy doses, routes of administration, and formulations that would facilitate individualization of remedy,” says Dr. Stephanie Faubion, medical director for The Menopause Society.
Extra data:
Search engine optimization H. Baik et al, Use of menopausal hormone remedy past age 65 years and its results on girls’s well being outcomes by sorts, routes, and doses, Menopause (2024). DOI: 10.1097/GME.0000000000002335
Quotation:
Ladies aged older than 65 years might be able to safely proceed taking hormone remedy (2024, April 10)
retrieved 10 April 2024
from https://medicalxpress.com/information/2024-04-women-aged-older-years-safely.html
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