Doxycycline tied to lower risk for C. difficile in pneumonia patients

For sufferers with community-acquired pneumonia (CAP), doxycycline is related to a lowered danger for Clostridioides difficile an infection (CDI), in response to a research printed on-line Nov. 1 within the American Journal of An infection Management.

Ashley L. O’Leary, Pharm.D., from the Veterans Affairs Western New York Healthcare System in Buffalo, and colleagues performed a retrospective analysis in hospitalized sufferers in Veterans Affairs Hospitals throughout the USA to look at whether or not doxycycline is related to lowered CDI danger.

Throughout the research timeframe, about 156,107 hospitalized sufferers obtained care at a Veterans Affairs Hospital and have been identified with CAP. The researchers discovered that in contrast with azithromycin, doxycycline used with ceftriaxone for the remedy of pneumonia was related to a 17 p.c reduced risk for CDI. The incidence of CDI was lowered by 45 p.c for sufferers who had a previous historical past of CDI (odds ratio, 0.55).

“Our evaluation discovered that in sufferers with a previous historical past of C. diff, doxycycline was the one issue related to a discount within the incidence of recent C. diff infections,” senior writer Kari A. Mergenhagen, Pharm.D., additionally from the Veterans Affairs of Western New York Healthcare System, mentioned in an announcement. “These outcomes counsel that in circumstances the place Legionella pneumonia will be dominated out previous to remedy, sufferers at elevated danger of C. diff might profit from using doxycycline as a first-line agent.”

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